-This addresses the potential underestimation of the $R_0$ estimate when using the ID method.
-The method of least squares is used to estimate $R_0$, and similar to the ID model, the serial interval is assumed to be known and this method is developed assuming the SIR model.
+This addresses the potential underestimation of the <em>R</em><sub>0</sub> estimate when using the ID method.
+The method of least squares is used to estimate <em>R</em><sub>0</sub>, and similar to the ID model, the serial interval is assumed to be known and this method is developed assuming the SIR model.